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I was told by the clinic that I attend to received my Methadone that it IS safe to take prednisone while taking Methadone. I am currently on my second prescription of prednisone and a Z-pack antibiotic for a chest cold and this time as with the last time I was on the antibiotics, the swelling in my hands, legs and feet that I have had due to the Methadone has gone completely away!! I have been having the side effects of extreme swelling and water retention since being on methadone, to the point to where I can hardly get my body out of the bed in the mornings, my joints ache and if I sit still for long periods of time the fluid in my body from the swelling settles in my legs, feet and joints so when I go to get up it usually takes me a minute or two, literally, to stand up and be capable of walking b/c I am so sore...but the prednisone makes that all go away within 48 hours of the medicine being in my system. I began my round of the predisone 2 days ago and this morning I awakend with NO fluid on my body and have felt WONDERFUL today!! I don't know if the results of this are typical for everyone, but I know it has made a HUGE difference for me and I feel just fine, no other side effects...but the bad part about this is about 5 days AFTER I complete my round of the prednisone the fluid slowly begins to build back up in my body resulting in the terrible pain and discomfort of the fluid retention...also, I am not sure if the dose mg makes a difference in how bad the swelling becomes, I have yet to ask my doctor that question...anyway, I hope my statement helps anyone who was asking about taking the two meds together!

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14y ago
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16y ago

Yes. There are no known drug interactions when taking suboxone with prednisone.

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15y ago

Yes, there is no problem in taking those 2 drugs together, as long as both are prescribed for the same person. Dizziness might be enhanced as long as both drugs cause this side effect.

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Q: Is it safe to take steroid Prednisone with suboxone?
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