No. A minor form of the blood disorder thalassemia is when you inherited just one beta thalassemia gene, along with a normal beta-chain gene. This manifests as mild anaemia with a slight lowering of the hemoglobin level in the blood. No treatment is require. By contrast, a thalassemia major, also known as Cooley's Disease, is when one is born with two genes for beta thalassemia and no normal beta-chain gene. This is a serious disorder.
Alpha thalassemia silent carrierAlpha thalassemia minor, also called alpha thalassemia traitHemoglobin H diseaseAlpha thalassemia major, also called hydrops fetalisBeta thalassemia minor, also called beta thalassemia traitBeta thalassemia intermediaBeta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemiaBeta-plus (ß+) thalassemiaMediterranean anemia
Beta thalassemia variant
have seen one of my friends sister had kid and all normal no complications...not thalassemia either.........beta and alpha i think there is 25% normal chance
If you have beta thalassemia trait and your partner has sickle cell trait there is a 25% chance of your child having sickle beta thalassemia.
Yes, A "carrier" of alpha thalassemia and of beta thalassemia can marry, but not to someone with any hemoglobinopathy. Prof. Kornfeld Pal
Symptoms of beta thalassemia major or Cooley's anemia don't appear at birth because babies still have what is known as the fetal hemoglobin, which consists of two alpha chains and two delta chains, but the baby has no beta chains and therefore protected from the disorder. The baby will eventually develop the beta chains though.
Beta-thalassemia is typically caused by mutations in the HBB gene located on chromosome 11. Common mutations include point mutations, deletions, or insertions in the HBB gene, leading to reduced or absent production of beta-globin chains in hemoglobin. These mutations disrupt the normal structure and function of hemoglobin, resulting in anemia and other symptoms associated with beta-thalassemia.
beta thalassemia
5 to 10 years
One can find more information about Beta Thalassema on a number of websites. Wikipedia, Genetics home reference and St. Jude Children's Research Hospital are some online pages available for someone seeking information about Beta Thalassemia.
Renal function in pediatric patients with beta-thalassemia major.