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Definition

Thrombocytopenia is any disorder in which there is an abnormally low amount of platelets. Platelets are parts of the blood that help blood to clot. This condition is sometimes associated with abnormal bleeding.

Causes, incidence, and risk factors

Thrombocytopenia is often divided into three major causes of low platelets:

  1. Low production of platelets in the bone marrow
  2. Increased breakdown of platelets in the bloodstream (called intravascular)
  3. Increased breakdown of platelets in the spleen or liver (called extravascular)

Disorders that involve low production in the bone marrow include:

  • Aplastic anemia
  • Cancer in the bone marrow
  • Cirrhosis (chronic liver disease)
  • Folate deficiency
  • Infections in the bone marrow (very rare)
  • Myelodysplasia
  • Vitamin B12 deficiency

Use of certain drugs may also lead to a low production of platelets in the bone marrow. The most common example is chemotherapy treatment.

Disorders that involve the breakdown of platelets include:

Symptoms
  • Bruising
  • Nosebleeds or bleeding in the mouth and gums
  • Rash (pinpoint red spots called petechiae)

Other symptoms may be present as well, depending on the cause of the condition. Mild thrombocytopenia can occur without symptoms.

Signs and tests

Complete blood count (CBC) shows low number of platelets. Blood clotting studies (PTT and PT) are normal.

Other tests that may help diagnose this condition include:

Treatment

Treatment depends on the cause of the condition. In some cases, a transfusion of platelets may be required to stop or prevent bleeding.

Expectations (prognosis)

The outcome depends on the disorder causing the low platelet counts.

Complications

Severe bleeding (hemorrhage) is the main complication. This can include:

  • Bleeding in the brain (intracranial hemorrhage)
  • Gastrointestinal bleeding (vomiting blood or blood in the stools)
  • Nosebleeds
Calling your health care provider

Call your healthcare provider if you experience unexplained bleeding or bruising.

Prevention

Prevention depends on the specific cause.

References

McMillan R. Hemorrhagic disorders: abnormalities of platelet and vascular function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 179.

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There is no known way to prevent thrombocytopenia.

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Excessive use of acetaminophen (Tylenol) could possibly lead to thrombocytopenia. (referenced from a clinical resource)

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Gestational thrombocytopenia is coded to 649.31 - coagulation defects complicating pregnancy and 287.49 for secondary (gestational)thrombocytopenia.

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Thrombocytosis is a condition where the body has more than 450,000 platelets. Having less than 150,000 platelets is called thrombocytopenia.

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Fetal anemia and thrombocytopenia

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Hypothermia is caused by being exposed to cold temperatures for too long. Thrombocytopenia hallucinations are caused by a low blood platelet count.

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Thrombocytopenia which occurs in multiple diseases such as Dengue Fever.

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The patient is most likely to hemorrhage in condition a) thrombocytopenia, which is a decrease in platelet count resulting in impaired blood clotting ability. This can increase the risk of bleeding and hemorrhage.

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You take her back to the doctor who diagnosed the thrombocytopenia and get treatment for her. Thrombocytopenia is low platelet count. In extreme cases she might need a transfusion of platelets. She might also need medication such as prednisone. The condition will not go away on its own, and she is at risk of bleeding internally. Platelets are the component of blood that is repsponsible for clotting.

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A severe deficiency in vitamin B12 (folic acid) can lower the platelet count in the blood, causing slower clotting and possible internal bleeding.

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Yes, Thrombocytopenia can be hereditary. I have it along with 4 of my 5 other siblings. Our father has it so it has been passed down through his side of the family. We have all had to have our spleens removed because of this.

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Due to DIC and decreased thrombopoiesis.

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HIT medically means Heparin-induced thrombocytopenia.

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Thrombotic Thrombocytopenia Purpura
Tender to Palpation (TTP)

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No, but sometimes those problems go together.

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Thrombocytopenia: Impaired production of platelets

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Persons with this condition easily bruise and can have episodes of excess bleeding (a hemorrhage).

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Thrombocytopenia: Impaired production of platelets

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idiopathic thrombocytopenic purpura

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The condition of insufficient blood clotting cells is referred to as thrombocytopenia. This is a condition where there is a low platelet count in the blood, leading to difficulties in forming blood clots and increasing the risk of excessive bleeding.

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thrombocytopenia results from insufficient amount of platelets and its caused by anything that suppresses the bone marrow such as bone marrow cancer, radiation, and certain drugs.

whereas hemophilia is a genetic disease and is the lack of any factors needed for clotting.

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A low platelet count, called thrombocytopenia, causes the blood to fail to clot easily. A healthy platelet count should be between 150,000 and 450,000 platelets per micro liter of blood. A level lower than 150,000 platelets indicates thrombocytopenia.

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Thrombocytopenia is the medical term meaning deficiency of platelets. -penia is the combining form meaning deficiency.

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Thrombocytopenia is the medical term that refers to a deficiency of clotting cells, specifically platelets, in the blood. It can lead to abnormal bleeding and bruising due to the decreased ability of the blood to clot properly.

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When platelets become low in your body, it can lead to a condition called thrombocytopenia. This can cause increased risk of bleeding and bruising, as platelets are essential for blood clotting. Severe cases of thrombocytopenia may require medical attention to prevent serious bleeding complications.

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This is called Thrombocytopenia and means that the body is low on platelets, a type of blood cell that helps your blood to clot when damage occurs to blood vessels. Depending on how low the platelet count is, individuals with Thrombocytopenia may bruise easily and experience nosebleeds or bleeding gums.

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Hematopoiesis occurs in the bone marrow. Leukemia is a kind of blood or bone marrow cancer which disrupts regular function and production of blood cells. A person with leukemia can not produce regular, healthy blood cells and that's why this person develop anemia.

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Thrombocytopenia is the medical term meaning deficiency of platelets. -penia is the combining form meaning shortage.

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The mild form, X-linked thrombocytopenia, is also caused by mutations in this same gene.

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The toxicity profile of this drug when administered systemically includes granulocytopenia, anemia and thrombocytopenia. The drug is in pregnancy category C

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Thrombocytopenia (which non-professionals call "thin blood") has nothing to do with diabetes, or vice versa.

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Thrombocytopenia is the medical term meaning a deficiency of clotting cells. -penia is the combining form meaning deficiency.

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Thrombocytopenia is a condition characterized by a low platelet count in the blood. Platelets are essential for blood clotting, so low levels can lead to increased risk of bleeding and bruising. Thrombocytopenia can be caused by various factors, including autoimmune disorders, medications, infections, and certain medical conditions.

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Because the most common syndromatic cause of thrombocyropenia is called ITP, or Idiopathic Thrombocytopenic Purpura

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The medical term for platelet is "thrombocyte." If you have a decreased amount of platelets, the condition is "thrombocytopenia" or thrombopenia.

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the color of platelets is purple. excessive amount of platelets in the blood(thrombocytopenia) may be manifested as purpura(purplish discoloration of the skin)

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