| Small nucleolar RNA SNORA46 |
 |
| Type: |
Gene; snRNA; guide; HACA-box; |
| 2° structure: |
Predicted; RNAFOLD; Moxon SJ |
| Seed alignment: |
Moxon SJ |
| Avg length: |
125.4 nucleotides |
| Avg identity: |
81% |
|
Small nucleolar RNA SNORA46 (also known as ACA46) is a non-coding RNA (ncRNA)
molecule which functions in the biogenesis (modification) of other small nuclear RNAs
(snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which
is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often
referred to as a 'guide RNA'. ACA46 was originally cloned from HeLa cells [1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved
H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA46 is predicted to guide the pseudouridylation of U649 of
18S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form
pseudouridine.
References
- ^ Kiss AM, Jady BE,
Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol. Cell. Biol. 24 (13):
5797-807. DOI:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
External links
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