Because Sandhoff disease and Tay-Sachs disease have similar clinical symptoms, distinguishing them requires biochemical analysis. This involves a test to measure enzyme activity of the two hexosaminidase enzymes.
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The prognosis for Sandhoff disease is poor. Affected babies usually do not survive past the age of three and typically, death occurs due to complications associated with respiratory infections.
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In Tay-Sachs disease, a mutation that affects the alpha subunit of the enzyme causes a deficiency in HexA. Sandhoff disease is caused by mutations that affect the beta subunit, rendering both the HexA and HexB enzymes deficient.
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The symptoms begin with motor deficits (lack of normal movement) and a characteristic startle reaction to various sounds. Babies with Sandhoff disease progressively deteriorate in terms of motor function, and they often have seizures and myoclonus
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There is no cure for Sandhoff disease, and treatment is based on lessening the symptoms once they begin. Medication is usually given to reduce seizures, for example, and a feeding tube may be inserted to prevent aspiration of feedings into the lungs.
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A typical physical feature of Sandhoff disease is the presence of cherry-red spots in the back of the eyes. Additionally, affected children have an abnormally enlarged head and appear to have a doll-like appearance.
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As Sandhoff disease is a recessive disorder, males and females are affected with equal frequency. This disorder is more common in people with non-Jewish descent, unlike Tay-Sachs disease, which is prevalent mainly in individuals with Jewish ancestry.
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At birth, infants tend to be without symptoms and usually do not develop them until approximately six months of age.
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George S. Schisler has written:
'Salmonid disease investigations' -- subject(s): Whirling disease, Trout
'Salmonid disease investigations' -- subject(s): Trout, Habitat, Whirling disease, Trout fisheries, Habitat surveys, Parasites
'Salmonid disease studies' -- subject(s): Trout, Habitat, Whirling disease, Trout fisheries, Habitat surveys, Parasites
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M. S. El-Sabban has written:
'Investigation on the epidemiology of Newcastle Disease \\' -- subject(s): Newcastle disease
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John Pearce has written:
'Migraine' -- subject(s): Migraine
'Parkinson's disease and its management' -- subject(s): Diagnosis, Parkinson Disease, Parkinson's disease, Therapy
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Peter H. R. Green has written:
'Celiac Disease' -- subject(s): Health & Fitness, Nonfiction, OverDrive
'Celiac Disease' -- subject(s): Health & Fitness, Nonfiction, OverDrive
'Celiac disease' -- subject(s): Celiac disease, Diseases, Intestines
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The celiac disease when the immune react to the protein gluten
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Howard S. Ginsberg has written:
'Ecology and management of ticks and lyme disease at Fire Island National Seashore and selected Eastern National Parks' -- subject(s): Lyme disease, Ticks as carriers of disease
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A. N. Lieberman has written:
'Shaking up Parkinson disease' -- subject(s): Parkinson's disease, Popular works
'Parkinson's disease' -- subject(s): Parkinson's disease, Popular works
'The Muhammad Ali Parkinson center 100 questions and answers about Parkinson disease'
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Another name for Pagetâ??s disease is ostetitis deformans. In general, there are no symptoms associated with Pagetâ??s disease. It is often detected when x-rays are performed for other reasons.
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May Sherman has written:
'Congenital heart disease' -- subject(s): Congenital heart disease, Research grants
'Respiratory tract in health and disease' -- subject(s): Diseases, Respiration, Respiratory organs
'Drugs and heart disease'
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Typcially, onset of symptoms with HD is from the mid 30-s to 40's.
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George Dock has written:
'Hookworm disease' -- subject(s): Hookworm disease
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A. Duchars has written:
'Dutch Elm disease' -- subject(s): Dutch elm disease
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Albin Holmgren has written:
'Handbook of disease outbreaks' -- subject(s): Epidemics, Communicable Disease Control, Disease Outbreaks
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Virginia Fraser has written:
'Understanding \\' -- subject(s): Alzheimer Disease, Alzheimer's disease, Popular works, Alzheimer's Disease
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Typcially, onset of symptoms with HD is from the mid 30-s to 40's.
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About the 1830's but it was able to be cured until the 1890's
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Lenore S. Powell has written:
'Alzheimer's disease'
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A disease is something serious.It can be something contagious, for example:Cancer;it's something serious and it can spread and it can cause you to die.
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Crohn's disease is an inflammatory bowel disease that affects the intestines and other areas of the digestive system.
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t.i.'s son died because of a deadly disease of head injury t.i.'s son died because of a deadly disease of head injury
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Herman K. Hellerstein has written:
'Coronary artery disease' -- subject(s): Coronary heart disease
'Healing your heart' -- subject(s): Coronary heart disease, Diet therapy, Exercise therapy, Recipes
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Edward Hindle has written:
'Flies in relation to disease' -- subject(s): Insects as carriers of disease, Diptera, Flies as carriers of disease, Flies
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Donald S. Clarke has written:
'AIDS the biblical solutions' -- subject(s): AIDS (Disease), Christianity, Religious aspects, Religious aspects of AIDS (Disease), Religious aspects of Sex, Sex
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James R. Busvine has written:
'Insects and hygiene' -- subject(s): Medical entomology, Veterinary entomology, Insects as carriers of disease
'Disease transmission byinsects' -- subject(s): Medical entomology, Insects as carriers of disease
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Sad to say, there still is no cure for Huntington's and cannot be treated except through Specialists in the disease.
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Michael Pollak has written:
'Les homosexuels et le sida' -- subject(s): AIDS (Disease), Diseases, Gay men, Social aspects of AIDS (Disease)
'AIDS: a problem for sociological research' -- subject(s): AIDS (Disease), Social aspects, Social aspects of AIDS (Disease)
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