Nootropic drugs are a fascinating area of study for those interested in enhancing cognitive function and brain health. One specific benefit that some nootropics offer is the improvement of brain blood circulation. Enhanced blood flow to the brain can lead to better oxygen and nutrient delivery, which supports overall brain function and health.
Several nootropics are known for their ability to improve cerebral blood circulation:
Ginkgo Biloba: This natural supplement is often praised for its ability to enhance blood flow to the brain, which can improve memory and cognitive function.
Vinpocetine: Derived from the periwinkle plant, vinpocetine is believed to increase blood flow to the brain, supporting cognitive abilities and protecting against neural damage.
Piracetam: A well-known member of the racetam family, piracetam may enhance brain blood flow and improve various aspects of cognitive function, including memory and learning.
For more detailed information on nootropics and their benefits, including how they can improve brain blood circulation, you can visit this comprehensive guide.
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Citicoline is a psychostimulant or nootropic drug. It belongs to the phosphatidylcholine generation of chemicals and is used to treat strokes, vision problems, and memory disorders.
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Aniracetam: a new nootropic agent for senile dementia
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pyramem is a nootropic. Used to increase blood and oxygen flow to stimulate brain activity. Used for degenerative memory problems and head trauma in eastern europe.
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D-Serine is an amino acid that a huge component formation of memories. It also offers a huge boost cognitive performance as well as memory. D-Serine is a must to add to any current Nootropic stack.
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Cognitive Energy Enhancers. They combine the brain boosting power of nootropics with powerful energy compounds to both enhance neural processing and improve responsiveness. They have become so successful, they are being called "adderall alternatives."
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Smart Drugs or Nootropics aren't necessarily new - they have been around since the 1960's... But what is new is the way they are being used. Leading products in the field of smart drugs are using Nootropic based stacks as cognitive enhancers.
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According to the website PROFIDERALL's Cognitive Energy Complex is the unique combination of nootropic "smart drugs" and powerful energy compounds:
Piracetam
Huperzine A
Vinpocetine
DMAE
Alpha-Lipoic Acid
Choline Bitartrate
Vitamin B6
Vitamin B12
Tyrosine
Taurine
Caffeine
Niacin
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OTC alternatives for healthy overachievers looking to improve mental performance can be found in supplements known as Cognitive Energy Enhancers. The use combination of a nootropic stack with powerful energy compounds to increase focus and boost energy - much like adderall
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Yes. I just received my PEA and can say smoking is highly euphoric. It does cut cravings too. If you want an all around nootropic that stimulates nicotinic acetylcholine receptors (diminishes the need to smoke) then look into Aniracetam.
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Always do your homework before taking a new substance. Most Nootropics are generally regarded as safe (GRAS) but none are approved to treat or cure any illness or disease. For a healthy person looking to gain an edge in school or life, Piracetam is the gold standard and the first nootropic you should start with. Many see an immediate effect but for most it may take weeks or months to notice a difference. Generally, the healthier you are the less noticeable the effects. Be sure to give ample time before discrediting Nootropics. Nootropics build with time so you're more likely to see a difference after six months than you are after three. The longer you take it, the more the effects build.
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L-Theanine, when added to a nootropic stack, can help improve focus, reduce anxiety, and enhance cognitive performance. It works well with other nootropics to promote a calm and alert state of mind, making it easier to concentrate and think clearly.
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Genuine FDA-approved Nootropics are available at the best price at Health Matter. One can get Nootropics without a prescription from the Health Matter online pharmacy. It offers popular Nootropics to treat sleep disorders and mental health issues. People who are looking for affordable Nootropic, health Matter is the best platform.
healthmatter.co/
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Alpha Brain is a nootropic supplement that contains ingredients like L-theanine and L-tyrosine, which may help reduce anxiety symptoms by promoting relaxation and improving focus and mental clarity. These ingredients work together to support a calm and balanced state of mind, potentially reducing feelings of anxiety.
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According to SOWPODS (the combination of Scrabble dictionaries used around the world) there are 3 words with the pattern N-O-R----. That is, nine letter words with 1st letter N and 3rd letter O and 5th letter R. In alphabetical order, they are:
neoprenes
neotropic
nootropic
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To get wakefulness and activeness for longer hours, Artvigil 150mg is the best solution. It is a nootropic band that is a stimulant that provides wakefulness. In addition to that, it enhances one's cognition ability, such as memory, concentration, motivation, etc. After 30 minutes of intake of the dose, users get more activeness and energy to work.
Visit the given link to get Atvigil 150mg online.
healthmatter.co/product/artvigil-150
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According to SOWPODS (the combination of Scrabble dictionaries used around the world) there are 4 words with the pattern N--TR--I-. That is, nine letter words with 1st letter N and 4th letter T and 5th letter R and 8th letter I. In alphabetical order, they are:
neotropic
neutronic
nontragic
nootropic
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Neuromin M is a combination Empowered right pair to enhance performance.
Mecobalamin is the biologically active form of vitamin B12, which is 130-150 times more potent than Cyanocobalamin.
Piracetam is a nootropic agent considered as a "smart drug", reported to enhance cognitive functions of the brain like memory, attention, intelligence, etc. Also protects brain tissue from various physical and chemical abrasions such as alcohol damage.
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Ceribram is a nootropic supplement that is designed to enhance cognitive functions such as memory, focus, and mental clarity. It typically contains a blend of natural ingredients, including herbal extracts and vitamins, that are believed to support brain health and improve overall cognitive performance. Users often take ceribram to help with mental fatigue, stress, or to boost productivity. However, its efficacy and safety can vary, and it's essential to consult a healthcare professional before starting any supplement regimen.
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A smart drug, also known as a nootropic, is a substance that aims to enhance cognitive function, memory, creativity, or motivation. These substances can include prescription medications, over-the-counter supplements, or natural compounds, but their effects and safety can vary widely. It's important to consult with a healthcare professional before using any smart drug to ensure it is safe and appropriate for you.
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Feltrex is a proprietary blend of ingredients used in some health supplements, often marketed for cognitive enhancement or overall wellness. While the specific formulation can vary by product, it typically includes a mix of vitamins, minerals, herbal extracts, and amino acids. Common components may include ingredients like bacopa monnieri, ginkgo biloba, or other nootropic substances aimed at improving mental clarity and focus. Always check the product label for the exact ingredients and consult with a healthcare professional before use.
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The legal status of nootropics in the UK varies depending on the specific substance. While many natural nootropics like Ginkgo Biloba and Rhodiola Rosea are legal and readily available, some synthetic nootropics, such as Modafinil and certain racetams, are regulated and may require a prescription. It's important to check the specific regulations for each nootropic you're interested in. For a detailed overview of nootropics and their legal status, you can visit this comprehensive guide.
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According to SOWPODS (the combination of Scrabble dictionaries used around the world) there are 26 words with the pattern NO-----I-. That is, nine letter words with 1st letter N and 2nd letter O and 8th letter I. In alphabetical order, they are:
nomologic
nonacidic
nonatomic
noncredit
noncrisis
noncyclic
nonerotic
nonethnic
nonexotic
nonfossil
nonheroic
nonliquid
nonmetric
nonpareil
nonpoetic
nonprofit
nonpublic
nonrhotic
nonstatic
nontragic
nonvirgin
nootropic
nosologic
nostalgia
nostalgic
notabilia
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According to SOWPODS (the combination of Scrabble dictionaries used around the world) there are 31 words with the pattern --OT---I-. That is, nine letter words with 3rd letter O and 4th letter T and 8th letter I. In alphabetical order, they are:
apothecia
azotaemia
azotaemic
egotistic
esotropia
esotropic
exotropia
exotropic
geotactic
geotropic
inotropic
isotactic
isotropic
neoteinia
neotropic
nootropic
ovotestis
photophil
photopsia
proteinic
proteomic
prothesis
prothetic
protistic
protoavis
protozoic
ryotwaris
scotophil
sooterkin
soothsaid
zoothecia
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You could but it would be a great waste of good drugs as the blockade effect of dopamine receptors of Suboxone with Bupe will also block some of the pleasurable and "nootropic" (stimulating) effects of the GHB. Better not to mix drugs at all. GHB is not a good one to mix anything with!
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There's not a single aspect of the human experience that hasn't been touched by technology. Everything from industry, to medicine, to how we work has been fundamentally reshaped by the technologies which emerged in the second half of the 20th century.
Technology can also change the human in terms of his or her characteristics and abilities. Want to be smarter? You can take a Nootropic. Want to perceive the world with more detail and more information? Put on Google Glasses. Want to get stronger or more physically agile? There are medicines or robotic exoskeletons.
Technology has moved away from merely making our lives more convenient, and now it has the potential to change every aspect of what we are as humans. We are becoming transhuman. But what does that mean?
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Words made from the letters from "cooperate" include:
Two letter words:
Three- letter words:
Four-letter words:
Five-letter words:
Six-letter words:
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In 1964, scientists at the Belgian pharmaceutical company UCB synthesised a substance now known as Piracetam. Dr. Corneliu E. Giurgea, who led the team that synthesized Piracetam, coined the new substance a "Nootropic" and later branded the product Nootropil. The scientists were amazed at the safety of Piracetam, even in large doses. They observed the ability of Piracetam to increase mental functioning both in healthy people and in individuals with diseased mental conditions, such as Alzheimer's and dementia. Dr. Giurgea came up with a set of criteria that substances had to meet in order to be considered a true nootropic.
Piracetam met all of these criteria and was subsequently the first substance labeled as a nootropic. Soon, many other compounds were derived from this new family of drugs called Racetams. From Piracetam, other Racetams such as Oxiracetam, Aniracetam, and Pramiracetam were developed and touted to be even more potent than the previous derivative. While each of the Racetams provide differing solubilities and potencies, they vary little in their effects. No one has been able to identify the exact mechanism of how Piracetam positively influences memory, but it is generally accepted that it enhances cerebral blood flow and protects brain cells from damage from oxygen deprivation. It is also said to increase communication between the left and right hemispheres of the brain through stimulation of the corpus callosum. In terms of safety, Piracetam has little, if any, side effects. One scientist said that it was safer than salt and described the potential side effects as "few, mild, and transient."
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Yes, they are called Cognitive Energy Enhancers. These nutritional supplements, like PROFIDERALL, are available over the counter and combine Nootropic Smart Drugs with powerful energy compounds to help increase focus and boost energy.
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Cognitive enhancement pouches are small, portable packets filled with a mix of nootropic ingredients, vitamins, and other supplements intended to improve mental performance. They come in various forms, including:
**Powder Pouches**: Designed to be mixed with water or other beverages.
**Chewable Pouches**: Edible pouches that can be consumed directly.
**Liquid Pouches**: Ready-to-drink shots for quick consumption.
**Caffeine**: A well-known stimulant that can enhance alertness and focus.
**L-Theanine**: Often combined with caffeine to promote calm and focus without the jittery effects of caffeine alone.
**Ginkgo Biloba**: Believed to improve blood flow to the brain and enhance cognitive function.
**Bacopa Monnieri**: An herb used for its potential memory-enhancing properties.
**Rhodiola Rosea**: Known for its adaptogenic properties, helping to reduce fatigue and improve mental performance.
**Vitamins and Minerals**: Such as B vitamins, which are crucial for brain health and energy production.
**Acetyl-L-Carnitine**: An amino acid that supports brain energy metabolism.
**Ginseng**: Often used for its potential to improve concentration and reduce mental fatigue.
**Enhanced Focus and Concentration**: Ingredients like caffeine and L-Theanine can improve alertness and attention span.
**Improved Memory**: Herbs like Bacopa Monnieri and Ginkgo Biloba are traditionally used to support memory and cognitive function.
**Increased Mental Energy**: Vitamins and amino acids can support overall brain health and energy levels.
**Stress Reduction**: Adaptogens like Rhodiola Rosea can help the body adapt to stress, promoting a calmer mind.
**Convenience**: These pouches are designed for on-the-go use, making them easy to carry and consume anywhere.
**Dosage**: Follow the recommended dosage instructions on the packaging to avoid potential side effects from overconsumption.
**Hydration**: Ensure adequate hydration when consuming these pouches, especially those containing stimulants like caffeine.
**Consult a Healthcare Professional**: Before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications.
**Potential Side Effects**: Be aware of possible side effects, such as jitteriness, headaches, or digestive issues, particularly from stimulants.
**Quality and Purity**: Choose products from reputable brands that provide transparency about their ingredients and sourcing.
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If you are talking about legal uses of Adderall, no, there are no over the counter ADHD drugs.
If you are talking about trying to use it as a stimulant, caffeine is the only safe stimulant.
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There is a new product out called PROFIDERALL that is an over the counter alternative to adderall. It is non-prescription strength, but I tried it and it definitely helped me focus and gave me a ton of energy.
Most people don't understand that Adderall is a strong drug, it is four different types of amphetamines, which are a controlled substance. You aren't going to find anything over-the-counter anymore similar to Adderall than caffeine probably. And if you have been taking Adderall for more than like 1-2 months, caffeine won't at all compare.
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Nootropics or nootropic based supplements. The most popular product on the market is still PROFIDERALL which combines nootropics with powerful energy compounds to enhance both neural processing and responsiveness.
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ADD/ADHD is a complex disorder that is only partially understood.
magnesium and zinc taken in concert one with the other.
There is not much research on supplements for treating ADHD, primarily because it is a brain based disorder and much of it arises from structural abnormalities--not temporary fluctuations in diets. However, I have spoken with therapists who adjust sugar intake not because of speculated hyperactive effect but because of differences in adrenal gland function or effects from sugar for ADHD, although I don't have a source for that.
A natural treatment that I DO have many resources for is exercise--regular exercise is likely the best natural treatment alternative or supplement for people with ADHD, largely because of its effects on the brain. This will have much more lasting and dramatic effects than a food supplement.
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According to SOWPODS (the combination of Scrabble dictionaries used around the world) there are 303 words with the pattern --OT-----. That is, nine letter words with 3rd letter O and 4th letter T. In alphabetical order, they are:
apotheces
apothecia
apothegms
azotaemia
azotaemic
azotemias
azotising
azotizing
azoturias
bioterror
biotoxins
biotrophs
bioturbed
blotchier
blotchily
blotching
blottiest
blottings
bootblack
booteries
bootikins
bootjacks
bootlaces
bootlasts
bootlicks
bootmaker
bootstrap
brothered
brotherly
clothiers
clothings
clothlike
clotpolls
clottered
clottiest
clottings
cloturing
cootching
cootikins
crotaline
crotalism
crotchets
crotchety
crotonbug
egotheism
egotising
egotistic
egotizing
emoticons
emotional
emotively
emotivism
emotivity
eroticise
eroticism
eroticist
eroticize
erotising
erotizing
erotology
esoterica
esoteries
esoterism
esotropia
esotropic
exoticism
exoticist
exotoxins
exotropia
exotropic
flotation
flotillas
footballs
footbaths
footboard
footcloth
footering
footfalls
footfault
footgears
foothills
footholds
footlight
footlings
footloose
footmarks
footmuffs
footnoted
footnotes
footpaces
footpages
footpaths
footplate
footposts
footprint
footraces
footrests
footropes
footrules
footslogs
footstalk
footstall
footsteps
footstock
footstone
footstool
footwalls
footwears
footweary
footwells
footworks
frothiest
frothless
frottages
frotteurs
geotactic
geotherms
geotropic
glottides
glottises
grotesque
grottiest
hootnanny
inotropic
isotactic
isotheral
isotheres
isotherms
isotopies
isotropic
knotgrass
knotholes
knottiest
knottings
knotweeds
knotworks
leotarded
myotonias
neoteinia
neotenies
neotenous
neoterics
neoterise
neoterism
neoterist
neoterize
neotoxins
neotropic
nootropic
ocotillos
ovotestes
ovotestis
photinias
photocell
photocopy
photofits
photogene
photogens
photogeny
photogram
photolyse
photolyze
photomaps
photomask
photonics
photophil
photopias
photoplay
photopsia
photoscan
photosets
photostat
phototaxy
phototube
phototype
phototypy
plotlines
plottages
plottered
plottiest
plottings
protamine
protamins
protandry
protanope
proteases
protected
protecter
protector
protegees
proteides
proteinic
protended
protenses
proteomes
proteomic
proteoses
protested
protester
protestor
proteuses
prothalli
protheses
prothesis
prothetic
prothorax
protistan
protistic
protoavis
protocols
protoderm
protogine
protogyny
protonate
protonema
protopods
protostar
prototype
protoxide
protoxids
protozoal
protozoan
protozoic
protozoon
protracts
protruded
protrudes
quotation
quotative
quotidian
quotients
quotition
rhotacise
rhotacism
rhotacist
rhotacize
rhoticity
riotously
rootholds
rootiness
rootsiest
rootstalk
rootstock
rootworms
ryotwaris
scotching
scotomata
scotomias
scotomies
scotophil
scotopias
shotfirer
shotholes
shotmaker
shotproof
slotbacks
smothered
smotherer
snottered
snottiest
sooterkin
sootflake
soothered
soothfast
soothings
soothlich
soothsaid
soothsays
sootiness
spotlight
spottable
spottiest
spottings
stottered
swottiest
swottings
toothache
toothcomb
toothfish
toothfuls
toothiest
toothings
toothless
toothlike
toothpick
toothsome
toothwash
toothwort
trothless
trotlines
trottings
trottoirs
ulotrichy
zootaxies
zootechny
zoothecia
zootheism
zoothomes
zootomies
zootomist
zootoxins
zootropes
zootrophy
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There are two possible answer for your question. You did not word it either way so I am going to give you two answers.
In short, there might have been. I would say drug use among people has roughly stayed the same. No matter how hard the government has tried to crack down, people still use drugs. Ever since ancient times, people have been trying to find new and innovative ways to make them feel different then what they currently feel now.
There was definitely more acid back then, and it was way more potent back then. The weed is better today because of the techniques for growing and making new strains has increased the potency and heartiness of the marijuana plant. People may say that potency is a bad thing with weed, but NO thay are misinformed. If you are talking health, then listen: If the person was smoking weed of yesteryear, it wouldn't be as potent as todays 20% THC weed.
The weed of yesteryear had an average potency of 8 percent, double todays average (in most locales). The reason that the more potent the healthier is that they have to smoke less material to feel the same effect. Just because it is more potent, doesnt mean its more dangerous. The smart individual will sample a hit and then wait, not smoke a whole joint.
The more potent it is, the less harmful smoke (which contains tars and combusted material from the plant) has to be inhaled for the desired effect. It's still the same THC in every bag of weed (no matter the potency). People just want you to think todays weed is worse and "harder" then the weed of the 60s. Marijuana has been proven to kill cancer cells along with hundreds of other benefits proven by scientific research.
People have also found new ways to smuggle drugs into continents that don't allow that sort of thing (what they are doing is waging a civil war against their own people).
The other answer is YES, YES, YES! There are more designer drugs today such as 2C-b and other designer drugs that chemists can make. I wasnt sure if you meant quantity or different kinds of drugs. You should have elaborated.
There are many many many more drugs available today then there was in the 60s. Every day, chemists could come up with certain chemicals that could be psychoactive that weren't here yesterday (let alone 50 years ago). Some drugs get easier to make because someone discovers an alternate synthesis for a particular compound.
We are also delving into the era of Nootropic drugs. They are also referred to as smart drugs, memory enhancers, and cognitive enhancers. They include drugs, supplements, nutraceuticals, and functional foods that are purported to improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
Each day as science and the medical community learn more and more about the human brain and how it works, we can create chemicals that do certain specific things, such as seeing things that aren't there, feeling euphoria without any side effects, feeling dizzy when you aren't spinning around and around...etc etc. The possibilities are virtually limitless. Only time will tell whether or not these things will be available to the public either legally, or, unfortunately, illegally.
Sorry for the rant , but at least you got an answer (though severely biased).
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Acetylcholine - synthesized from Choline, Lecithin, and panthothenic acid (B5), or Diethylaminoethanol (DMAE)
- Arousal and orgasm
- voluntary muscular control and proper tone
- enhance energy and stamina
- memory
- long-term planning
- mental focus
Dopamine - synthesized from amino acid Levodopa
- Alertness
- Motivation
- motor control
- immune function
- Ego hardening, confidence, optimism
- Sexual Desire
- Fat gain and loss
- lean muscle gain
- Bone density
- ability to sleep soundly
- Inhibits prolactin
- thinking, planning, and problem solving
- Aggression
- Increase psychic and creative ability
- Reduction of compulsivety
- Salience and paranoia
- Processing of pain
- Increase sociability
Serotonin (5-HT) - Synthesized from amino acid L-tryptophan with co-factor Niacin (B3), through the intermediate 5-hydroxytryptophan (5-HTP)
- Decrease thought
- Anaesthesize emotions
- Decrease Agression and anger
- Decrease Anxiety
- Promote satiety and decrease appetite
- Elevates Pain threshold
- Reduces compulsivety/impulsivety
- Decrease Sexual Desire
- Orgasm
- Thermoregulation (5-HT1A)
- Stimulate Emesis (5-HT3)
- Cerebrospinal fluid secretion (5-HT2C)
- Platelate aggregation (5-HT2A)
- Smooth muscle contraction, vasoconstriction, and vasodilation (5-HT2A)
- Release oxytocin (5-HT1A)
- Learning (5-HT2A & 5-HT4)
- Memory (5-HT4)
- Neuronal excitation (5-HT2A, 5-HT3, & 5-HT4)
- GI motility (5-HT4)
- Neuronal inhibition (5-HT1A)
- Cerebral vasoconstriction (5-HT1D)
- Pulmonary vasoconstriction (5-HT1B)
- Presynaptic inhbition (5-HT1B)
Norepinephrine - Synthesized from Dopamine with co-factor of vitamin C through the intermediate DOPAC.
- Increase physical energy
- Reduce compulsivety
- Increase heart rate
- Increase BP
- Aggression
- Alertness
- Wakefulness/sleep cycle
- Memory and learning
- Orgasm
- Decrease blood flow to extremities
- Increase heart rate
- Maintenance of attention
- Orgasm
- Cerebral plasticity
Epinephrine - Synthesized from Norepinephrine. Also know as adrenaline, acts as both neurotransmitter and hormone. Oxidizes into Adrenochrome.
- increases supply of oxygen and glucose to brain and muscles
- Surpresses digestion
- Increase heart rate and stroke volume
- Pupil dilation
- constricts arterioles in skin and GI tract
- Dilates arterioles in skeletal muscles
- Elevates blood sugar levels
GABA - synthesized from glutamate
- Reduce physical tension
- Reduce Anxiety
- Reduce Insomnia
- Elevates pain threshold
- Reduces blood pressure
- Decrease heart rate
- Reduce compulsivety
Prolactin
- Inhibition of Dopamine
- Decreases sex hormones - estrogen in women, testosterone in men
- Stimulates proliferation of oligodendrocyte precursor cells.
These cells differentiate into oligodendrocytes, the cells
responsible for the formation of myelin coatings on axons in the central nervous system.
Nitric oxide
- vasodilation, thins blood
- reduces platelate stickiness, blood coagulation, wound healing
- vasopressin release
- stimulation of guanyl cyclase > GTP > cGMP. GMP lays a role in the relaxation of smooth muscle (including penis to facilitate erection), the inhibition of platelet aggregation and participates in signal transduction within the nervous system. Moreover, cGMP is involved in the regulation of the water and electrolyte balance as well as in the metabolism of the bone. cGMP is also involved
in retinal phototransduction--that is the conversion of a light signal received by a nerve receptor, to an electrical signal transmitted to the brain. This might help explain transcendental vision, that is the radical increase in visual acuity and sensory perception in general.
- involved in apoptosis, and DNA breakage and mutation
- enables macrophages to kill tumor cells and bacteria
Histamine - synthesized from L-histidine with co-factors folic acid, niacin, and copper.
H1
- Vasodilation
- Bronchoconstriction
- Smooth muscle activation
- separation of endothelial cells (responsible for hives)
- Pain and itching due to insect stings
- Allergic rhinitis
- Motion sickness
H2
- stimulates gastric acid secretion
- Potent stimulant of cAMP production
- increases the intracellular Ca2+ concentrations and release Ca2+ from intracellular stores.
H3
- presynaptically inhibits the release of a number of other neurotransmitters including, but probably not
limited to dopamine, histamine, GABA, acetylcholine, noradrenaline, and 5-HT. It leads to inhibition of the formation of cAMP
H4
- H4 Receptors mediate Chemotaxis and Calcium Mobilization of Mast Cells
Vasopressin
- Water retention
- raises blood pressure by inducing moderate vasoconstriction (AVPR1A)
- Platellate aggregation (AVPR1A)
- involved in aggression, blood pressure regulation and temperature regulation.
- It has been implicated in memory formation, including delayed reflexes, image, short- and long-term memory (controversial)
- increases peripheral vascular resistance and thus increases arterial blood pressure
- adrenocorticotropic hormone secretion in response to stress (AVPR1B)
- social interpretation of olfactory cues (AVPR1B)
- Gluconeogenesis (AVPR1A)
- Social Recognition (AVPR1A)
- Increases mental clarity and memory when used as nootropic
Oxytocin
- spontaneous erections and orgasm
- water retention (slight)
- inhibition of adrenocorticotropic hormone, cortisol, and vasopressin
- bonding
- decreased repetitive behaviors and improved interpretation of emotions
- Maternal behaviour
- increased trust and reduced fear
- Affecting generosity by increasing empathy during perspective taking.
- inhibition of development of tolerance to various drugs (opiates, cocaine, alcohol), and reduced withdrawals.
- impair learning and memory retrieval in certain aversive memory tasks
Endocannabinoids - synthesized from an essential fatty acid. Endogenous cannabinoids include anandamine, 2-AG, Noladin Ether, NADA, and OAD
- reduce GABA release in interneurons of the basolateral amygdala, thereby helping to extinguish the fear-conditioned response.
- Memory
- Development of opiate tolerance
- control of appetite and food intake
- long term potentiation
Endogenous opioids - Include Enkephalin, Beta-endorphin, Dynorphin, Endomorphin, Nociceptin, opiorphin, and morphine. Enkephalin is the ligand for delta receptors and also has a high affinity for Mu-opioid receptors. Dynorphin is the ligand for kappa receptors. Beta-endorphin has an affinity for mostly Mu, but also delta and kappa. Endomorphin is the ligand for Mu. Nociceptin for ORL receptors. Opiorphin is found in saliva and inhibits the enzyme that breaks down Enkephalin and B-Endorphin called Enkephalinase. Little is know about the role of Morphine in the body, but speculating from the effects of exogenous morphine, it would bind to Mu-receptors.
Mu-1
- Supraspinal Analgesia
- Physical dependence
Mu-2
- Respiratory depression
- Miosis
- Euphoria
- Reduced GI motility
- Physical dependence
Kappa
- Spinal Analgesia
- Sedation
- Inhibition of vasopressin release
- Miosis
Delta
- Anti-depressant effects
- Analgesia
- Physical dependence
ORL
- Depression
- Appetite
- Anxiety
- Development of tolerance to mu-agonists
Sigma Receptors - Little is know about these enigmatic receptors, but possible ligands include DHEA (sigma 1), and endogenous N, N-DMT with slight affinity for both sigma receptors. Effects of sigma receptor stimulation include:
- hypertonia (increased muscle tension)
- tachycardia
- tachypnea (increased breathing rate)
- mydriasis (pupil dilation)
- Euphoria or dysphoria
- anti-depressant effects
Other neurotransmitters include
Glycine
Glutamate and Aspartate - excitatory neurotransmitters that bind to the NMDA receptor. Can be synthesized from L-glutamine, glucose, or lipids. A metabolite of tryptophan in the absence of Niacin may produce kyunerinic acid, is also an NMDA excitatory neurotransmitter.
Melatonin - Synthesized from the methylation of serotonin. Regulates circadian rhythms and has powerful anti-oxidant effects.
Trace Amines - Include tryptamine, Phenylethylamine, tyramine, octopamine, 3-iodothyronamine, and others. Bind to the TAAR receptors.
GHB - bind to GHB receptor(s), and GABAb subunit receptor.
Niacin - Also know as vitamin B3, also acts as a neurotransmitter
Orexin - Also know as hypocretin. Plays a role in wakefullness and appetite.
- Yan Niemczycki
Note: There are four criteria by which neurotransmitters are defined.
1. It must be synthesized in the presynaptic cell.
2. It must be released by the presynaptic terminal in sufficient quantities to produce a measurable effect on the postsynaptic cell.
3. When administered artificially, it mimics natural release.
4. A specific, known mechanism exists for it to be removed from the synaptic cleft.
Of all the neurochemicals listed here, the following ten actually fit this definition. The remainder are all neuromodulators.
1. Glutamate
2. GABA
3. Glycine
4. Epinephrine (adrenaline)
5. Norepinephrine (noradrenaline)
6. Dopamine
7. Serotonin
8. Acetylcholine
9. Histamine
10. ATP/adenosine
5 answers
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