Results for isoflurane
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Drug Info:

Isoflurane

Brand names: Forane®



Isoflurane inhalation liquid

What is isoflurane inhalation liquid?

ISOFLURANE (Forane®) is used for general anesthesia during surgery and cesarean section. In addition to controlling pain and making you unconscious, general anesthesia control the body's reaction to stress and relieves fear and anxiety associated with surgery. You may receive more than one kind of anesthesia during your surgery or procedure. General anesthesia is commonly used for extensive and long surgeries, but also can be used in shorter and limited procedures. Generic isoflurane inhalation solution is available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• history of malignant hyperthermia
• myasthenia gravis
• an unusual or allergic reaction to isoflurane, or other anesthetics
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Isoflurane is given through inhalation (breathing the gas into the lungs) by trained anesthesia professionals in a controlled environment like an operating room before and during surgery or procedures. Since there is no one ideal general anesthetic, a combination of drugs that are either injected or inhaled are typically used.

What if I miss a dose?

This does not apply.

What drug(s) may interact with isoflurane?

• alcohol
• amiodarone
• doxapram
• herbal products, including St. John's wort
• isoniazid, INH
• levodopa
• medicines for colds, breathing difficulties, or weight loss
• medicines for high blood pressure, including beta-blockers
• medicines that improve muscle strength or tone for conditions like myasthenia gravis
• medicines for seizures
• rifampin
• theophylline
• warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking isoflurane?

You will be closely monitored following anesthesia with isoflurane.

Isoflurane can affect your ability to drive or do anything that needs mental alertness for about 24 hours after anesthesia. Do not attempt to drive yourself home if you have received isoflurane for minor outpatient surgery. You may not think clearly or notice changes in your mood for 2—3 days after receiving isoflurane.

You may feel dizzy and lightheaded. To reduce the risk of dizzy or fainting spells, do not sit up or stand up quickly, especially if you are an older patient. Alcohol can make you more drowsy or dizzy, avoid alcoholic drinks for at least 24 hours after you receive isoflurane.

What side effects may I notice from using isoflurane?

During your surgery or procedure the anesthesiologist will closely monitory all your body systems and treat any serious side effects. Side effects that you should report to your prescriber or health care professional as soon as possible:
• hallucinations
• high body temperature
• irregular heartbeat
• lightheadedness or fainting spells
• slow or difficult breathing
• yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• drowsiness
• headache
• muscle weakness
• nausea, vomiting
• shivering
• trembling

Where can I keep my medicine?

This does not apply as you only received general anesthetics in a hospital or clinic setting.


Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

 
 
Medical Dictionary: i·so·flu·rane
(ī'sō-flʊr'ān')
n.

A halogenated ether with potent anesthetic action.

 

A chlorofluorocarbon used as an inhalational anesthetic; known also as Forthane or Forane.

 
WordNet: isoflurane
Note: click on a word meaning below to see its connections and related words.

The noun has one meaning:

Meaning #1: a widely used inhalation anesthetic


 
Wikipedia: isoflurane
Isoflurane2.png
Isoflurane-3D-vdW.png
Isoflurane
Systematic (IUPAC) name
2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane
Identifiers
CAS number 26675-46-7
ATC code N01AB06
PubChem 3763
DrugBank APRD00212
Chemical data
Formula C3H2ClF5O 
Mol. mass 184.5 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Isoflurane (2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane) is a halogenated ether used for inhalational anesthesia. Together with enflurane and halothane, it replaced the flammable ethers used in the pioneer days of surgery. Its use in human medicine is now starting to decline, being replaced with sevoflurane, desflurane and the intravenous anaesthetic propofol. Isoflurane is still frequently used for veterinary anaesthesia.

Isoflurane is always administered in conjunction with air and/or pure oxygen. Often nitrous oxide is also used. Although its physical properties means that anaesthesia can be induced more rapidly than with halothane, its pungency can irritate the respiratory system, negating this theoretical advantage conferred by its physical properties. It is usually used to maintain a state of general anesthesia that has been induced with another drug, such as thiopentone or propofol. It vaporizes readily, but is a liquid at room temperature. It is completely non-flammable.

A major advantage of isoflurane is that the patent covering its use has expired, therefore it is very economical to use.

Physical properties

Molecular weight 184.5g/mol
Boiling point (at 1 atm): 48.5 °C
Density (at 25 °C): 1.496 g/mL
MAC : 1.15 vol %
Vapor pressure: 238 mmHg 31.7 kPa (at 20°C)
295 mmHg 39.3 kPa (at 25°C)
367 mmHg 48.9 kPa (at 30°C)
450 mmHg 60.0 kPa (at 35°C)
Water Solubility Insoluble
Blood:Gas Partition coefficient: 1.4
Oil:Gas Partition coefficient: 98

Mechanism of action

Isoflurane reduces pain sensitivity (analgesia) and relaxes muscles. The mechanism by which general anesthetics produce the anesthetic state is not clearly understood but likely involves interactions with multiple receptor sites to interfere with synaptic transmission. Isoflurane binds to GABA receptors, glutamate receptors and glycine receptors, and also inhibits conduction in activated potassium channels. Glycine inhibition helps to inhibit motor function, while bonding to glutamate receptors mimics the efects of NDMA. It activates calcium ATPase through an increase in membrane fluidity, and binds to the D subunit of ATP synthase and NADH dehydrogenase. In addition, a number of general anesthetics attenuate gap junction commmunication, which could contribute to anesthetic action.

Possible link to cognitive decline

Isoflurane exposure has been shown to induce cognitive decline in mice.[1] Exposure of cultured human cells to isoflurane has been reported to induce apoptosis and accumulation and aggregation of amyloid beta protein.[2] Further research will be required to establish whether or not clinical exposure to isoflurane leads to dementia (Alzheimer's disease).[3][4]

References

  1. ^ S. L. Bianchi, T. Tran, C. Liu, S. Lin, Y. Li, J. M. Keller, R. G. Eckenhoff, M. F. Eckenhoff (2007). "Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics". Neurobiology of Aging 28 (in press): in press. DOI:10.1016/j.neurobiolaging.2007.02.009. 
  2. ^ Z. Xie, Y. Dong, U. Maeda, R. D. Moir, W. Xia, D. J. Culley, G. Crosby, R. E. Tanzi (2007). "The Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Amyloid ß-Protein Accumulation". Journal of Neuroscience 27 (6): 1247-1254. DOI:10.1523/JNEUROSCI.5320-06.2007. 
  3. ^ M. C. Lewis, I. Nevoa, M. A. Paniaguaa, A. Ben-Aric, E. Prettoa, S. Eisdorfera, E. Davidsona, I. Matotc, C. Eisdorfer (2007). "Uncomplicated general anesthesia in the elderly results in cognitive decline: Does cognitive decline predict morbidity and mortality?". Medical Hypotheses 68 (3): 484-492. DOI:10.1016/j.mehy.2006.08.030. 
  4. ^ Reinberg, Steven. "Anesthetic Linked to Alzheimer's Risk", HealthDay News, 15 January 2007. Retrieved on 2007-08-08. 

External links


 
 

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Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Medical Dictionary. The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
WordNet. WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.  Read more
Wikipedia. This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Isoflurane" Read more

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