intestine

 

muscular hoselike portion of the gastrointestinal tract extending from the lower end of the stomach (pylorus) to the anal opening. In humans this fairly narrow (about 1 in./2.5 cm) tubelike structure winds compactly back and forth within the abdominal cavity for about 23 ft (7 m), and is known as the small intestine. It is not only an organ of digestion (for that part of the process not completed by the stomach) but is the chief organ of absorption. By contraction of its muscular walls (peristalsis) the food mass is propelled onward and, as it is carried along, it is subject to the digestive action of the secretions of the intestinal lining as well as to that of bile and pancreatic juice which enter the upper intestine (duodenum) from ducts leading from the liver and pancreas. Innumerable minute projections (villi) in the intestinal mucous lining absorb the altered food for distribution by the blood and lymphatic systems to the rest of the body. Food continues to pass into the middle (jejunum) and end (ileum) of the small intestines. The small intestine joins the large intestine (colon) at the cecum in the right lower abdominal cavity. Here, also, is the appendix, a blind pouch projecting from the cecum. The large intestine is wider in diameter. Its direction as it leaves the cecum is upward (ascending colon), across the abdominal cavity (transverse colon) beneath the stomach, and then downward (descending colon) on the left side of the abdominal cavity, making a sharp turn in the left lower portion (sigmoid) to merge with the rectum. In all, the large intestine is about 5 ft (1.5 m) long. Bacteria, the indigestible residue of food, and mucus form the bulk of matter in the large intestine. The water content of the bulk is absorbed through the walls of the large intestine, and the solid matter is excreted through the rectum. See digestive system.

In anatomy, the intestine is the segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. In humans, the small intestine is further subdivided into the duodenum, jejunum and ileum while the large intestine is subdivided into the cecum and colon.

Structure and Function

The intestinal tract can be broadly divided into two different parts, the small and large intestine. Grayish-purple in color and about 35 mm (1.5 inches) in diameter, the small intestine is the first and longest, measuring 6-8 metres (22-25 feet) on average in an adult man. Shorter and relatively stockier, the large intestine is a dark reddish color, measuring roughly 1.5 metres (5 feet) on average. Both intestines share a general structure with the whole gut, and are composed of several layers. The lumen is the cavity where digested material passes through and from where nutrients are absorbed. Along the whole length of the gut in the glandular epithelium are goblet cells. These secrete mucus which lubricates the passage of food along and protects it from digestive enzymes. Villi are vaginations of the mucosa and increase the overall surface area of the intestine while also containing a lacteal, which is connected to the lymph system and aids in the removal of lipids and tissue fluid from the blood supply. Micro villi are present on the epithelium of a villus and further increase the surface area over which absorption can take place.

The next layer is the muscularis mucosa which is a layer of smooth muscle that aids in the action of continued peristalsis along the gut. The submucosa contains nerves, blood vessels and elastic fibre with collagen that stretches with increased capacity but maintains the shape of the intestine. Surrounding this is the muscularis externa which comprises longitudinal and smooth muscle that again helps with continued peristalsis and the movement of digested material out of and along the gut.

Lastly there is the serosa which is made up of loose connective tissue and coated in mucus so as to prevent friction damage from the intestine rubbing against other tissue. Holding all this in place are the mesenteries which suspend the intestine in the abdominal cavity and stop it being disturbed when a person is physically active.

The large intestine hosts several kinds of bacteria that deal with molecules the human body is not able to breakdown itself. This is an example of symbiosis. These bacteria also account for the production of gases inside our intestine (this gas is released as flatulence when removed through the anus). However the large intestine is mainly concerned with the absorption of water from digested material (which is regulated by the hypothalamus), the reabsorption of sodium, as well as any nutrients that may have escaped primary digestion in the ileum.

Absorption of glucose in the ileum

Initially, nutrients diffuse passively from the lumen of the ileum via the epithelial cells and into the blood stream. However, certain molecules like glucose passively diffuse in mass quantity some time after a meal, causing a change in concentration gradient. This results in a higher concentration of glucose in the blood (blood sugar level) than in the ileum, such that passive diffusion is no longer possible. Active uptake would be a waste of energy, so another process is used to transport the left-over glucose from the lumen into the blood stream.

In this process, called secondary active transport, a glucose molecule associates with a sodium ion and approaches a transporter protein in the membrane of an epithelial cell. The protein allows the sodium ion through, which then "pulls" the glucose molecule into the cell. Once inside the cell, the sodium and glucose dissociate, and the glucose molecule is free to diffuse passively from the cell into the blood stream (this is because the blood flowing past the cell has a lower blood sugar level than the cell cytoplasm).

Diseases

• Gastroenteritis is inflammation of the intestines and is the most common disease of the intestines. It can arise as the result of food poisoning.
• Ileus is a blockage of the intestines.
• Ileitis is an inflammation of the ileum.
• Colitis is an inflammation of the large intestine.
• Appendicitis is inflammation of the vermiform appendix located at the cecum. This is a potentially fatal disease if left untreated; most cases of appendicitis require surgical intervention.
• Coeliac disease is a common form of malabsorption, affecting up to 1% of people of northern European descent. Allergy to gluten proteins, found in wheat, barley and rye, causes villous atrophy in the small intestine. Life-long dietary avoidance of these foodstuffs in a gluten-free diet is the only treatment.
• Crohn's disease and ulcerative colitis are examples of inflammatory bowel disease. While Crohn's can affect the entire gastrointestinal tract, ulcerative colitis is limited to the large intestine. Crohn's disease is widely regarded as an autoimmune disease. Although ulcerative colitis is often treated as though it were an autoimmune disease, there is no consensus that it actually is such. (See List of autoimmune diseases).
• Enteroviruses are named by their transmission-route through the intestine (enteric = related to intestine), but their symptoms aren't mainly associated with the intestine.

Disorders

• Irritable bowel syndrome is the most common functional disorder of the intestine. Functional constipation and chronic functional abdominal pain are other disorders of the intestine that have physiological causes, but do not have identifiable structural, chemical, or infectious pathologies. They are aberrations of normal bowel function but not diseases.

• Diverticular disease is a condition that is very common in older people in industrialized countries. It usually affects the large intestine but has been known to affect the small intestine as well. Diverticular disease occurs when pouches form on the intestinal wall. Once the pouches become inflamed it is known as Diverticulitis, or Diverticular disease.

• Endometriosis can affect the intestines, with similar symptoms to IBS.

• Bowel twist (or similarly, bowel strangulation) is a comparatively rare event (usually developing sometime after major bowel surgery). It is, however, hard to diagnose correctly, and if left uncorrected can lead to bowel infarction and death. (The singer Maurice Gibb is understood to have died from this.)

References

This article or section is missing citations or needs footnotes. Using inline citations helps guard against copyright violations and factual inaccuracies.

• Encyclopædia Britannica article on intestine retrieved on 2007-03-27
• KMLE Medical Dictionary definition of intestine retrieved from KMLE Medical Dictionary on 2007-03-27

See also

• Inflammatory bowel disease (or "IBD")
• Diarrhea
• Constipation

Anatomy of torso, digestive system: Gastrointestinal tract
Upper GI: to stomach	Mouth • Pharynx (nasopharynx, oropharynx, hypopharynx) • Esophagus • Crop
Upper GI: stomach	rugae - gastric pits - cardia/gland - fundus/gland - pylorus/gland - pyloric antrum - greater curvature - lesser curvature
Lower GI: intestines	Small intestine (duodenum, jejunum, ileum) • Vermiform appendix • Ileocecal valve - Large intestine: Cecum • Colon (ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, sigmoid colon)
Lower GI: after intestines	Rectum (Houston valve, rectal ampulla, pectinate line) • Anal canal (anal valves, anal sinuses, anal columns) - Anus: Sphincter ani internus muscle • Sphincter ani externus muscle
Lower GI: continuous	GALT: Peyer's patches • M cells - intestinal villus • crypts of Lieberkühn • circular folds • taenia coli • haustra • epiploic appendix

Human anatomy, endocrine system: endocrine glands
Hypothalamic/pituitary axes	Adrenal axis (Adrenal gland) • Thyroid axis (Thyroid gland, Parathyroid gland) • Gonadal axis (Testes, Ovaries, Corpus luteum)
Other	Pineal gland • Islets of pancreas

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